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USP34
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Belongs to the peptidase C19 family. Expressed in brain at low level. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease |
| Chromosomal Location of rat Ortholog: 14q22 |
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Cellular Component:
cytosol; nucleus
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Molecular Function:
cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity
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Biological Process:
positive regulation of canonical Wnt signaling pathway; protein deubiquitination; protein K48-linked deubiquitination; ubiquitin-dependent protein catabolic process
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Reference #:
NP_001258125
(RefSeq)
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Alt. Names/Synonyms: ubiquitin carboxyl-terminal hydrolase 34; ubiquitin specific peptidase 34; Usp34
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Gene Symbols: Usp34
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Molecular weight:
408,156 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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