SYNE1 iso6 Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Belongs to the nesprin family. Expressed in HeLa, A431, A172 and HaCaT cells (at protein level). Widely expressed. Highly expressed in skeletal and smooth muscles, heart, spleen, peripheral blood leukocytes, pancreas, cerebellum, stomach, kidney and placenta. Isoform GSRP-56 is predominantly expressed in heart and skeletal muscle (at protein level). 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Membrane protein, integral; RNA-binding
Chromosomal Location of Human Ortholog: 1q11
Cellular Component:  cytoplasm; dendritic spine; dendritic spine head; Golgi apparatus; integral component of membrane; meiotic nuclear membrane microtubule tethering complex; midbody; nuclear envelope; nuclear membrane; nucleolus; nucleoplasm; P-body; perinuclear region of cytoplasm; postsynaptic membrane; sarcomere; spindle
Molecular Function:  actin binding; actin filament binding; enzyme binding; identical protein binding; lamin binding; protein binding; protein homodimerization activity; signaling receptor binding; structural molecule activity
Biological Process:  brain development; cardiac muscle cell differentiation; centrosome localization; cytoskeletal anchoring at nuclear membrane; Golgi organization; muscle cell differentiation; negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; nuclear matrix anchoring at nuclear membrane; nuclear migration; positive regulation of mesenchymal cell proliferation; positive regulation of receptor-mediated endocytosis; regulation of cilium assembly; regulation of dendrite morphogenesis; regulation of nucleus organization; regulation of postsynaptic neurotransmitter receptor internalization; response to light stimulus
Reference #:  D3ZEA8 (UniProtKB)
Alt. Names/Synonyms: CPG2; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; Syne1; SYNE1 iso6
Gene Symbols: Syne1
Molecular weight: 315,795 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
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SYNE1 iso6

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein