NRAGE Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: X C3|X 41.56 cM
Cellular Component:  chromatin; cytoplasm; membrane; nucleus; plasma membrane; protein-containing complex
Molecular Function:  identical protein binding; protein binding; transcription coactivator activity
Biological Process:  circadian regulation of gene expression; negative regulation of epithelial cell proliferation; negative regulation of transcription, DNA-templated; positive regulation of apoptotic signaling pathway; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of MAP kinase activity; positive regulation of transcription, DNA-templated; regulation of apoptotic process; regulation of circadian rhythm; regulation of transcription by RNA polymerase II; rhythmic process
Reference #:  Q9QYH6 (UniProtKB)
Alt. Names/Synonyms: 2810433C11Rik; 5430405L04Rik; Dlixin; Dlxi; Dlxin-1; Dlxin1; DXBwg1492e; FLJ00163; MAGD1; MAGE family member D1; MAGE-D; MAGE-D1; MAGE-D1 antigen; Maged1; melanoma antigen, family D, 1; Melanoma-associated antigen D1; mFLJ00163; Neurotrophin receptor-interacting MAGE homolog; Nrage; OTTMUSP00000019650; RP23-272D10.5
Gene Symbols: Maged1
Molecular weight: 85,670 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene