KI-67 iso4 Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus
Chromosomal Location of Human Ortholog: 1q41
Cellular Component:  chromosome, centromeric region; condensed chromosome; cytoplasm; nuclear body; nucleolus; nucleoplasm; nucleus
Molecular Function:  protein C-terminus binding
Biological Process:  animal organ regeneration; cell proliferation; cellular response to heat; cholangiocyte proliferation; DNA metabolic process; hepatocyte proliferation; hyaluronan metabolic process; meiotic cell cycle; regulation of chromatin organization; regulation of chromosome segregation; regulation of mitotic nuclear division; response to organic cyclic compound
Reference #:  XP_006230515 (RefSeq)
Alt. Names/Synonyms: antigen identified by monoclonal antibody Ki-67; KI-67 iso4; marker of proliferation Ki-67; Mki67
Gene Symbols: Mki67
Molecular weight: 356,790 Da
Basal Isoelectric point: 9.75  Predict pI for various phosphorylation states
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KI-67 iso4

Protein Structure Not Found.


Cross-references to other databases:  GeneCards  |  Entrez-Gene  |  GenPept  |  Ensembl Gene