VIPAS39 Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin. Belongs to the SPE39 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 12|12 D2
Cellular Component:  cytoplasm; cytoplasmic vesicle; early endosome; endosome; Golgi apparatus; late endosome; recycling endosome
Molecular Function:  protein-containing complex binding
Biological Process:  cell differentiation; collagen fibril organization; collagen metabolic process; intracellular protein transport; peptidyl-lysine hydroxylation; post-translational protein modification; protein transport; spermatogenesis
Reference #:  Q8BGQ1 (UniProtKB)
Alt. Names/Synonyms: 6720456H09Rik; 9330175H22Rik; AI413782; CN133; Spermatogenesis-defective protein 39 homolog; Uncharacterized protein C14orf133 homolog; Vipar; VPS33B interacting protein, apical-basolateral polarity regulator
Gene Symbols: Vipar
Molecular weight: 56,625 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein