COLEC11 iso9 Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. Belongs to the COLEC10/COLEC11 family. Ubiquitous (PubMed:17179669). Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level) (PubMed:20956340). 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p25.3
Cellular Component:  collagen trimer; extracellular region; extracellular space
Molecular Function:  calcium ion binding; calcium-dependent carbohydrate binding; DNA binding; fucose binding; mannose binding; oligosaccharide binding; protein binding
Biological Process:  antimicrobial humoral response; complement activation; complement activation, lectin pathway; developmental process; execution phase of apoptosis; multicellular organism development; receptor-mediated endocytosis
Reference #:  Q9BWP8-9 (UniProtKB)
Alt. Names/Synonyms: CL-K1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CLK1; COL11; COLEC11; collectin kidney I; Collectin kidney protein 1; collectin sub-family member 11; Collectin-11; DKFZp686N1868; MGC3279
Gene Symbols: COLEC11
Molecular weight: 29,006 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
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COLEC11 iso9

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein