COLEC11 iso9 Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p25.3
Cellular Component:  collagen trimer; extracellular region; extracellular space
Molecular Function:  calcium ion binding; calcium-dependent carbohydrate binding; DNA binding; fucose binding; mannose binding; oligosaccharide binding; protein binding
Biological Process:  antimicrobial humoral response; complement activation; complement activation, lectin pathway; developmental process; execution phase of apoptosis; multicellular organism development; receptor-mediated endocytosis
Reference #:  Q9BWP8-9 (UniProtKB)
Alt. Names/Synonyms: CL-K1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CLK1; COL11; COLEC11; collectin kidney I; Collectin kidney protein 1; collectin sub-family member 11; Collectin-11; DKFZp686N1868; MGC3279
Gene Symbols: COLEC11
Molecular weight: 29,006 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
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COLEC11 iso9

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein