CRMP-4 iso2 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 18p11-q11
Cellular Component:  cell body; cytosol; extracellular space; filamentous actin; growth cone; lamellipodium; synapse
Molecular Function:  chondroitin sulfate binding; filamin binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; phosphoprotein binding; SH3 domain binding
Biological Process:  actin crosslink formation; actin filament bundle assembly; cellular response to cytokine stimulus; negative regulation of cell migration; negative regulation of neuron projection development; nervous system development; neuron development; positive regulation of filopodium assembly; positive regulation of neuron projection development; protein homooligomerization; response to axon injury
Reference #:  Q62952-2 (UniProtKB)
Alt. Names/Synonyms: CRMP-4; CRMP-4 iso2; Crmp4; dihydropyrimidinase-like 3; Dihydropyrimidinase-related protein 3; Dpysl3; TUC-4b
Gene Symbols: Dpysl3
Molecular weight: 73,899 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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CRMP-4 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene