ARSB Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Belongs to the sulfatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.6.12; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase
Chromosomal Location of rat Ortholog: 2q12
Cellular Component:  cell surface; Golgi apparatus; lysosome; mitochondrion; rough endoplasmic reticulum
Molecular Function:  arylsulfatase activity; metal ion binding; N-acetylgalactosamine-4-sulfatase activity; sulfuric ester hydrolase activity
Biological Process:  anterior head development; autophagy; central nervous system development; colon epithelial cell migration; positive regulation of neuron projection development; regulation of epithelial cell migration; response to estrogen; response to methylmercury; response to nutrient; response to pH
Reference #:  P50430 (UniProtKB)
Alt. Names/Synonyms: ARSB; Arylsulfatase B
Gene Symbols: Arsb
Molecular weight: 58,959 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
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ARSB

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene