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DBNL
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Belongs to the ABP1 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 11 A1|11 3.87 cM |
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Cellular Component:
cell cortex; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton; dendrite; endosome; Golgi apparatus; lamellipodium; membrane; plasma membrane; podosome; postsynaptic density; ruffle; synapse
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Molecular Function:
actin binding; actin filament binding; protein binding; protein C-terminus binding; protein domain specific binding
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Biological Process:
adaptive immune response; endocytosis; immune system process; neuron projection morphogenesis; podosome assembly; Rac protein signal transduction; receptor-mediated endocytosis; ruffle assembly; synapse assembly
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Reference #:
Q62418
(UniProtKB)
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Alt. Names/Synonyms: Abp1; Actin-binding protein 1; Dbnl; drebrin-like; Drebrin-like protein; mAb; mAbp1; OTTMUSP00000005311; SH3; SH3 domain-containing protein 7; Sh3p7
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Gene Symbols: Dbnl
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Molecular weight:
48,700 Da
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Basal Isoelectric point:
4.9
Predict pI for various phosphorylation states
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