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CENTB1
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 11|11 B3 |
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Cellular Component:
cytoplasm; endosome; membrane
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Molecular Function:
GTPase activator activity; metal ion binding
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Biological Process:
lipid catabolic process; lipid metabolic process; signal transduction
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Reference #:
Q8K2H4
(UniProtKB)
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Alt. Names/Synonyms: Acap1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; centaurin, beta 1; Centaurin-beta-1; Centb; Centb1; Cnt-b1; Kiaa0050; MGC25782; MGC47358; OTTMUSP00000006244
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Gene Symbols: Acap1
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Molecular weight:
81,704 Da
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Basal Isoelectric point:
7.32
Predict pI for various phosphorylation states
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