CENTB1 GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11|11 B3
Cellular Component:  endosome; membrane
Molecular Function:  GTPase activator activity; hydrolase activity; metal ion binding
Biological Process:  lipid catabolic process; lipid metabolic process; signal transduction
Reference #:  Q8K2H4 (UniProtKB)
Alt. Names/Synonyms: Acap1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; centaurin, beta 1; Centaurin-beta-1; Centb; Centb1; Cnt-b1; Kiaa0050; MGC25782; MGC47358; OTTMUSP00000006244
Gene Symbols: Acap1
Molecular weight: 81,704 Da
Basal Isoelectric point: 7.32  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene