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PPP1R14A
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Protein phosphatase, regulatory subunit |
| Chromosomal Location of Human Ortholog: 7|7 B1 |
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Cellular Component:
cytoplasm
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Molecular Function:
protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity
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Biological Process:
cellular response to drug; regulation of phosphorylation
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Reference #:
Q91VC7
(UniProtKB)
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Alt. Names/Synonyms: 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; CPI-17; Cpi17; PP14A; Ppp1r14a; Protein kinase C-potentiated inhibitor protein of 17 kDa; Protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A
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Gene Symbols: Ppp1r14a
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Molecular weight:
16,649 Da
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Basal Isoelectric point:
6.84
Predict pI for various phosphorylation states
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