|
PPP1R14A
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Inhibitor; Protein phosphatase, regulatory subunit |
| Chromosomal Location of Human Ortholog: 7|7 B1 |
|
Cellular Component:
cytoplasm
|
|
Molecular Function:
protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity
|
|
Biological Process:
cellular response to drug; regulation of phosphorylation
|
|
Reference #:
Q91VC7
(UniProtKB)
|
|
Alt. Names/Synonyms: 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; Cpi; CPI-17; Cpi17; PP14A; Ppp1r14a; Protein kinase C-potentiated inhibitor protein of 17 kDa; Protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A; protein phosphatase 1, regulatory inhibitor subunit 14A
|
|
Gene Symbols: Ppp1r14a
|
|
Molecular weight:
16,649 Da
|
|
Basal Isoelectric point:
6.84
Predict pI for various phosphorylation states
|
