PPP1R14A Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  cytoplasm
Molecular Function:  protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity
Biological Process:  cellular response to drug; regulation of phosphorylation
Reference #:  Q91VC7 (UniProtKB)
Alt. Names/Synonyms: 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; CPI-17; Cpi17; PP14A; Ppp1r14a; Protein kinase C-potentiated inhibitor protein of 17 kDa; Protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A
Gene Symbols: Ppp1r14a
Molecular weight: 16,649 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
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PPP1R14A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene