|
PAH
Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase |
| Chromosomal Location of human Ortholog: 12q23.2 |
|
Cellular Component:
cytosol
|
|
Molecular Function:
iron ion binding; phenylalanine 4-monooxygenase activity
|
|
Biological Process:
amino acid biosynthetic process; catecholamine biosynthetic process; L-phenylalanine catabolic process; neurotransmitter biosynthetic process; tyrosine biosynthetic process; tyrosine biosynthetic process, by oxidation of phenylalanine
|
|
Disease: Phenylketonuria
|
|
Reference #:
P00439
(UniProtKB)
|
|
Alt. Names/Synonyms: PAH; PH; PH4H; Phe-4-monooxygenase; phenylalanine 4-monooxygenase; phenylalanine hydroxylase; Phenylalanine-4-hydroxylase; PKU; PKU1
|
|
Gene Symbols: PAH
|
|
Molecular weight:
51,862 Da
|
|
Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
|
