YB-1 Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4|4 D2.1
Cellular Component:  CRD-mediated mRNA stability complex; cytoplasm; cytoplasmic stress granule; cytosol; dendrite; extracellular region; histone pre-mRNA 3'end processing complex; intracellular membrane-bounded organelle; messenger ribonucleoprotein complex; neuronal cell body; nuclear membrane; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex; U12-type spliceosomal complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; GTPase binding; mRNA binding; nucleic acid binding; p53 binding; protein binding; RNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; single-stranded DNA binding; transcription factor binding
Biological Process:  cellular response to interleukin-7; CRD-mediated mRNA stabilization; in utero embryonic development; mRNA processing; negative regulation of apoptotic process; negative regulation of insulin receptor signaling pathway; negative regulation of striated muscle cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of transcription by RNA polymerase II; protein localization to cytoplasmic stress granule; regulation of transcription, DNA-templated; RNA splicing
Reference #:  P62960 (UniProtKB)
Alt. Names/Synonyms: 1700102N10; 1700102N10Rik; C79409; CBF-A; CCAAT-binding transcription factor I subunit A; dbp; DBPB; DNA binding protein B; DNA-binding protein B; EF1; EF1A; EFI-A; Enhancer factor I subunit A; MGC118070; MSY; Msy-1; Msy1; mYB-1a; Nsep1; nuclease sensitive element binding protein 1; Nuclease-sensitive element-binding protein 1; OTTMUSP00000009615; Y box protein 1; Y-box binding protein 1; Y-box transcription factor; Y-box-binding protein 1; YB-1; Yb1; YBOX1; Ybx1
Gene Symbols: Ybx1
Molecular weight: 35,730 Da
Basal Isoelectric point: 9.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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YB-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene