TUBB Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 17|17 B1
Cellular Component:  cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; intercellular bridge; membrane raft; microtubule; microtubule cytoskeleton; mitotic spindle; nuclear envelope lumen; nucleus; protein-containing complex; tubulin complex
Molecular Function:  GTP binding; GTPase activating protein binding; GTPase activity; metal ion binding; MHC class I protein binding; nucleotide binding; protein domain specific binding; protein-containing complex binding; structural constituent of cytoskeleton; ubiquitin protein ligase binding
Biological Process:  microtubule cytoskeleton organization; microtubule-based process; mitotic cell cycle; odontoblast differentiation; regulation of synapse organization; spindle assembly
Reference #:  P99024 (UniProtKB)
Alt. Names/Synonyms: AA408537; AI596182; B130022C14Rik; M(beta)5; TBB5; TUBB; Tubb5; Tubulin beta-5 chain; tubulin, beta 5; tubulin, beta 5 class I
Gene Symbols: Tubb5
Molecular weight: 49,671 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TUBB

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein