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SIT
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 4|4 A5 |
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Cellular Component:
integral component of membrane; membrane; plasma membrane
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Molecular Function:
kinase binding
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Biological Process:
adaptive immune response; immune system process; regulation of T cell activation; signal transduction; T cell homeostasis
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Reference #:
Q8C503
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000007334; SHP2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; Signaling threshold-regulating transmembrane adapter 1; Sit; Sit1; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1
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Gene Symbols: Sit1
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Molecular weight:
19,578 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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