SIT Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 4|4 A5
Cellular Component:  integral component of membrane; membrane; plasma membrane
Molecular Function:  kinase binding
Biological Process:  adaptive immune response; immune system process; regulation of T cell activation; signal transduction; T cell homeostasis
Reference #:  Q8C503 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000007334; SHP2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; Signaling threshold-regulating transmembrane adapter 1; Sit; Sit1; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1
Gene Symbols: Sit1
Molecular weight: 19,578 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene