SHC1 iso7 Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. Widely expressed. Expressed in neural stem cells but absent in mature neurons. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  cytosol; mitochondrial matrix; plasma membrane; Shc-EGFR complex
Molecular Function:  ephrin receptor binding; epidermal growth factor binding; epidermal growth factor receptor binding; insulin receptor binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phospholipid binding; phosphotyrosine residue binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  actin cytoskeleton reorganization; activation of MAPK activity; angiogenesis; axon guidance; cell-cell adhesion; cellular response to growth factor stimulus; cytokine-mediated signaling pathway; defense response to bacterium; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; Fc-epsilon receptor signaling pathway; heart development; insulin receptor signaling pathway; interleukin-15-mediated signaling pathway; interleukin-2-mediated signaling pathway; IRE1-mediated unfolded protein response; leukocyte migration; MAPK cascade; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-templated; Ras protein signal transduction; regulation of epidermal growth factor-activated receptor activity; regulation of growth; viral process
Reference #:  P29353-7 (UniProtKB)
Alt. Names/Synonyms: SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; SHC1; SHC1 iso7
Gene Symbols: SHC1
Molecular weight: 51,682 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
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SHC1 iso7

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein