UBE1 an enzyme of the ubiquitin-activating E1 family. Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. Belongs to the ubiquitin-activating E1 family. Detected in erythrocytes (at protein level). Ubiquitous. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: X A1.3|X 16.15 cM
Cellular Component:  cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus
Molecular Function:  ATP binding; ligase activity; nucleotide binding; protein binding; ubiquitin activating enzyme activity; ubiquitin-like modifier activating enzyme activity
Biological Process:  cellular protein modification process; cellular response to DNA damage stimulus; protein modification by small protein conjugation; protein ubiquitination
Reference #:  Q02053 (UniProtKB)
Alt. Names/Synonyms: A1S9; AA989744; OTTMUSP00000018598; OTTMUSP00000018662; Sbx; Uba1; Ube-1; Ube1; Ube1ax; Ube1x; Ubiquitin-activating enzyme E1; Ubiquitin-activating enzyme E1 X; ubiquitin-activating enzyme E1, Chr X; ubiquitin-like modifier activating enzyme 1; Ubiquitin-like modifier-activating enzyme 1; Ubiquitin-like modifier-activating enzyme 1 X
Gene Symbols: Uba1
Molecular weight: 117,809 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene