RP1 May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. Belongs to the MAPRE family. Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 18 A2|18 12.08 cM
Cellular Component:  cytoplasm; cytoplasmic microtubule; cytoskeleton; focal adhesion; microtubule; microtubule cytoskeleton; microtubule organizing center; microtubule plus-end; spindle midzone
Molecular Function:  identical protein binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding
Biological Process:  cell cycle; cell division; positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; positive regulation of GTPase activity; positive regulation of keratinocyte migration; protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; spindle assembly
Reference #:  Q8R001 (UniProtKB)
Alt. Names/Synonyms: AI314113; APC-binding protein EB1; APC-binding protein EB2; C820009F03Rik; D18Abb1; D18Abb1e; EB1; EB2; End-binding protein 2; Mapre2; MARE2; Microtubule-associated protein RP/EB family member 2; microtubule-associated protein, RP/EB family, member 2; RP1; T-cell activation protein, EB1 family, member 2
Gene Symbols: Mapre2
Molecular weight: 36,946 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene