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RP1
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. Belongs to the MAPRE family. Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 18 A2|18 12.08 cM |
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Cellular Component:
cytoplasm; cytoplasmic microtubule; cytoskeleton; focal adhesion; microtubule; microtubule cytoskeleton; microtubule organizing center; microtubule plus-end; spindle midzone
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Molecular Function:
identical protein binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding
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Biological Process:
cell cycle; cell division; positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; positive regulation of GTPase activity; positive regulation of keratinocyte migration; protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; spindle assembly
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Reference #:
Q8R001
(UniProtKB)
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Alt. Names/Synonyms: AI314113; APC-binding protein EB1; APC-binding protein EB2; C820009F03Rik; D18Abb1; D18Abb1e; EB1; EB2; End-binding protein 2; Mapre2; MARE2; Microtubule-associated protein RP/EB family member 2; microtubule-associated protein, RP/EB family, member 2; RP1; T-cell activation protein, EB1 family, member 2
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Gene Symbols: Mapre2
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Molecular weight:
36,946 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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