WIBG Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. Belongs to the pym family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 10|10 D3
Cellular Component:  cell junction; cytoplasm; cytosol; exon-exon junction complex; nucleolus; nucleus
Molecular Function:  ribosome binding; RNA binding
Biological Process:  exon-exon junction complex disassembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; regulation of translation
Reference #:  Q8CHP5 (UniProtKB)
Alt. Names/Synonyms: A030010B05Rik; Partner of Y14 and mago; Protein wibg homolog; Pym; PYM homolog 1 exon junction complex-associated factor; PYM homolog 1, exon junction complex associated factor; PYM1; Wib; Wibg; within bgcn homolog; within bgcn homolog (Drosophila)
Gene Symbols: Wibg
Molecular weight: 22,690 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene