PAR3-alpha an adapter protein involved in asymmetrical cell division, and cell polarization processes. Polarity complex proteins, including PARD3, are essential for PIP3-induced receptor tyrosine kinase recycling. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. PDZ 1 domain modulates interactions with JAM1, PARD6A and PARD6B; PDZ 2 domain mediates interaction with membranes containing phosphoinositol lipids; PDZ 3 domain regulates interactions with PTEN (via C-terminus). Belongs to the PAR3 family. 10 isoforms of the human protein are produced by alternative splicing. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8 E2|8 74.66 cM
Cellular Component:  adherens junction; apical junction complex; apical part of cell; apical plasma membrane; axonal growth cone; bicellular tight junction; cell cortex; cell junction; cell-cell adherens junction; cell-cell junction; cytoplasm; cytoskeleton; internode region of axon; lateral loop; membrane; neuronal cell body; plasma membrane; protein-containing complex; Schmidt-Lanterman incisure; spindle
Molecular Function:  identical protein binding; lipid binding; phosphatidylinositol binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein phosphatase binding
Biological Process:  apical constriction; bicellular tight junction assembly; cell adhesion; cell cycle; cell differentiation; cell division; cell-cell adhesion; centrosome localization; establishment of cell polarity; establishment of centrosome localization; establishment of epithelial cell polarity; establishment or maintenance of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; microtubule cytoskeleton organization; myelination in peripheral nervous system; negative regulation of peptidyl-threonine phosphorylation; positive regulation of myelination; positive regulation of receptor internalization; protein localization; protein targeting to membrane; regulation of actin filament-based process; regulation of cellular localization; wound healing, spreading of cells
Reference #:  Q99NH2 (UniProtKB)
Alt. Names/Synonyms: AA960621; AI256638; ASIP; Atypical PKC isotype-specific-interacting protein; D8Ertd580e; Ephrin-interacting protein; PAR-3; par-3 (partitioning defective 3) homolog (C. elegans); par-3 family cell polarity regulator; Par3; PARD-3; Pard3; Partitioning defective 3 homolog; PHIP
Gene Symbols: Pard3
Molecular weight: 149,075 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Microtubule Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene