RhoGDI beta Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. Belongs to the Rho GDI family. Detected in bone marrow, thymus and spleen. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6|6 G1
Cellular Component:  cytoplasm; cytosol; membrane
Molecular Function:  GTPase activator activity; GTPase activity; Rac GTPase binding; Rho GDP-dissociation inhibitor activity
Biological Process:  negative regulation of trophoblast cell migration; regulation of actin cytoskeleton reorganization; regulation of Rho protein signal transduction; Rho protein signal transduction
Reference #:  Q61599 (UniProtKB)
Alt. Names/Synonyms: Arhgdib; D4; Gdid4; GDIR2; Ly-GDI; OTTMUSP00000027098; OTTMUSP00000027099; OTTMUSP00000027100; Rho GDI 2; Rho GDP-dissociation inhibitor 2; Rho, GDP dissociation inhibitor (GDI) beta; Rho-GDI beta
Gene Symbols: Arhgdib
Molecular weight: 22,851 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
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RhoGDI beta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene