SRC-1 Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. Belongs to the SRC/p160 nuclear receptor coactivator family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12|12 A1.1
Cellular Component:  cytoplasm; cytosol; neuron projection; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; protein-containing complex
Molecular Function:  aryl hydrocarbon receptor binding; chromatin binding; DNA binding; enzyme binding; estrogen receptor binding; histone acetyltransferase activity; nuclear hormone receptor binding; nuclear receptor binding; nuclear receptor transcription coactivator activity; progesterone receptor binding; protein binding; protein dimerization activity; protein N-terminus binding; protein-containing complex binding; retinoic acid receptor binding; retinoid X receptor binding; RNA polymerase II regulatory region DNA binding; transcription coactivator activity; transcription factor binding; transferase activity; transferase activity, transferring acyl groups
Biological Process:  cellular response to hormone stimulus; cellular response to Thyroglobulin triiodothyronine; histone H4 acetylation; labyrinthine layer morphogenesis; male mating behavior; positive regulation of apoptotic process; positive regulation of female receptivity; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-templated; regulation of cellular response to drug; regulation of RNA biosynthetic process; regulation of thyroid hormone mediated signaling pathway; regulation of transcription, DNA-templated; response to estradiol; response to progesterone; response to retinoic acid; transcription, DNA-templated
Reference #:  P70365 (UniProtKB)
Alt. Names/Synonyms: bHLHe74; KAT13A; MGC90703; mNRC-1; NCoA-1; Ncoa1; Nuclear receptor coactivator 1; Nuclear receptor coactivator protein 1; SRC-1; SRC-a/NCoA-1; Src1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Gene Symbols: Ncoa1
Molecular weight: 157,016 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SRC-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA