SRC-1 a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component:  cytosol; neuron projection; nuclear chromatin; nucleoplasm; plasma membrane; protein-containing complex
Molecular Function:  androgen receptor binding; aryl hydrocarbon receptor binding; chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen receptor binding; histone acetyltransferase activity; nuclear hormone receptor binding; nuclear receptor binding; nuclear receptor transcription coactivator activity; progesterone receptor binding; protein binding; protein dimerization activity; protein N-terminus binding; protein-containing complex binding; retinoid X receptor binding; RNA polymerase II regulatory region DNA binding; transcription coactivator activity
Biological Process:  androgen receptor signaling pathway; bile acid and bile salt transport; cellular response to Thyroglobulin triiodothyronine; cerebellum development; cerebral cortex development; estrous cycle; hippocampus development; histone H4 acetylation; hypothalamus development; labyrinthine layer morphogenesis; lactation; male gonad development; male mating behavior; positive regulation of apoptotic process; positive regulation of female receptivity; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-templated; regulation of cellular response to drug; regulation of lipid metabolic process; regulation of thyroid hormone mediated signaling pathway; response to estradiol; response to progesterone; response to retinoic acid; transcription, DNA-templated
Reference #:  Q15788 (UniProtKB)
Alt. Names/Synonyms: bHLHe42; BHLHE74; Class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; MGC129719; MGC129720; NCoA-1; NCOA1; Nuclear receptor coactivator 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Gene Symbols: NCOA1
Molecular weight: 156,757 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SRC-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein