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RAD52
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. Belongs to the RAD52 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of human Ortholog: 12p13.33 |
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Cellular Component:
nucleoplasm; nucleus; protein-containing complex; protein-DNA complex
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Molecular Function:
DNA binding; identical protein binding; protein binding; single-stranded DNA binding
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Biological Process:
cellular response to oxidative stress; DNA double-strand break processing involved in repair via single-strand annealing; DNA recombinase assembly; DNA recombination; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via single-strand annealing; mitotic recombination; regulation of nucleotide-excision repair
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Reference #:
P43351
(UniProtKB)
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Alt. Names/Synonyms: DNA repair protein RAD52 homolog; RAD52; RAD52 homolog (S. cerevisiae); RAD52 homolog, DNA repair protein; recombination protein RAD52; rhabdomyosarcoma antigen MU-RMS-40.23
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Gene Symbols: RAD52
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Molecular weight:
46,169 Da
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Basal Isoelectric point:
8.49
Predict pI for various phosphorylation states
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CST Pathways:
G2/M DNA Damage Checkpoint
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