CD3Z
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). Belongs to the CD3Z/FCER1G family. CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs) (PubMed:11722641). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Membrane protein, integral; Receptor, misc. |
Chromosomal Location of mouse Ortholog: 1 H2.3|1 73.14 cM |
Cellular Component:
alpha-beta T cell receptor complex; cytoplasm; Fc-gamma receptor III complex; Golgi apparatus; membrane; plasma membrane; T cell receptor complex
|
Molecular Function:
identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase binding; transmembrane signaling receptor activity
|
Biological Process:
adaptive immune response; cell surface receptor signaling pathway; Fc-gamma receptor signaling pathway; immune system process; interleukin-2 production; positive regulation of protein localization to cell surface; protein-containing complex assembly; T cell receptor signaling pathway
|
Reference #:
P24161
(UniProtKB)
|
Alt. Names/Synonyms: 4930549J05Rik; A430104F18; A430104F18Rik; AW552088; Cd247; CD247 antigen; Cd3; CD3 antigen, zeta polypeptide; CD3-et; CD3-eta; CD3-zet; CD3-zeta; CD3-zeta/eta; Cd3h; Cd3z; CD3zet; CD3zeta; T-cell receptor T3 eta chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface glycoprotein CD3 eta chain; T-cell surface glycoprotein CD3 zeta chain; T3z; TCR; TCRk; Tcrz
|
Gene Symbols: Cd247
|
Molecular weight:
18,637 Da
|
Basal Isoelectric point:
9.32
Predict pI for various phosphorylation states
|
CST Pathways:
T Cell Receptor Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|