SIRT7 NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. Belongs to the sirtuin family. Class IV subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-; Nucleolus
Chromosomal Location of Human Ortholog: 10q32.3
Cellular Component:  cytoplasm; nuclear telomeric heterochromatin; nucleolus; nucleolus organizer region; nucleus
Molecular Function:  chromatin binding; histone deacetylase activity; metal ion binding; NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process:  histone H3 deacetylation; histone H4 deacetylation; negative regulation of transcription by RNA polymerase II; positive regulation of transcription involved in exit from mitosis; rRNA transcription
Reference #:  B2RZ55 (UniProtKB)
Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; Regulatory protein SIR2 homolog 7; RGD1305876; SIR2-like protein 7; Sirt7; sirtuin 7
Gene Symbols: Sirt7
Molecular weight: 45,113 Da
Basal Isoelectric point: 9.75  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SIRT7

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Pfam  |  ENZYME  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein