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BDP1
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Expressed in brain, colon and several tumor-derived cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) |
| Chromosomal Location of Human Ortholog: 1 B|1 13.25 cM |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity
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Biological Process:
blastocyst formation; dephosphorylation; protein dephosphorylation
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Reference #:
Q61152
(UniProtKB)
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Alt. Names/Synonyms: Fetal liver phosphatase 1; FLP-1; Flp1; HSCF; protein tyrosine phosphatase, non-receptor type 18; PTN18; PTP-HSCF; PTP-K1; Ptpk1; Ptpn18; Tyrosine-protein phosphatase non-receptor type 18
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Gene Symbols: Ptpn18
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Molecular weight:
50,202 Da
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Basal Isoelectric point:
8.57
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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