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ARRB2
a member of the arrestin/beta-arrestin protein family that function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating receptor desensitization. Also play roles in receptor resensitization processes. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Expressed at high levels in the CNS and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 11 B3|11 42.99 cM |
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Cellular Component:
basolateral plasma membrane; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; endocytic vesicle; endosome; glutamatergic synapse; intracellular anatomical structure; membrane; nucleoplasm; nucleus; plasma membrane; postsynaptic membrane
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Molecular Function:
14-3-3 protein binding; alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; arrestin family protein binding; D1 dopamine receptor binding; enzyme binding; follicle-stimulating hormone receptor binding; G protein-coupled receptor binding; identical protein binding; mitogen-activated protein kinase binding; molecular adaptor activity; platelet activating factor receptor binding; protein binding; protein domain specific binding; protein kinase B binding; protein-containing complex binding; signaling receptor binding; type 1 angiotensin receptor binding; type 2A serotonin receptor binding; ubiquitin protein ligase binding
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Biological Process:
adult walking behavior; cell chemotaxis; desensitization of G protein-coupled receptor signaling pathway by arrestin; detection of temperature stimulus involved in sensory perception of pain; endocytosis; follicle-stimulating hormone signaling pathway; G protein-coupled receptor internalization; G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of GTPase activity; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein phosphorylation; negative regulation of protein ubiquitination; negative regulation of release of cytochrome c from mitochondria; negative regulation of signal transduction; negative regulation of smooth muscle cell apoptotic process; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell differentiation; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of epithelial cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; postsynaptic signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; receptor internalization; regulation of G protein-coupled receptor signaling pathway; regulation of protein phosphorylation; signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway
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Reference #:
Q91YI4
(UniProtKB)
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Alt. Names/Synonyms: AI326910; Arr3; Arrb2; arrestin 3; Arrestin beta-2; arrestin, beta 2; AW122872; beta arr2; Beta-arrestin-2; beta-arrestin2; OTTMUSP00000006315; OTTMUSP00000006318; RP23-42P20.7
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Gene Symbols: Arrb2
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Molecular weight:
46,314 Da
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Basal Isoelectric point:
7.58
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Hedgehog Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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