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4E-BP2
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Belongs to the eIF4E-binding protein family. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of mouse Ortholog: 10 B4|10 32.21 cM |
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Cellular Component:
cytoplasm; intracellular non-membrane-bounded organelle; neuronal ribonucleoprotein granule; postsynapse
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Molecular Function:
eukaryotic initiation factor 4E binding; protein binding; translation repressor activity
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Biological Process:
insulin receptor signaling pathway; memory; modulation of chemical synaptic transmission; negative regulation of translation; negative regulation of translational initiation; regulation of synaptic plasticity; regulation of translation; regulation of translational initiation; social behavior; TOR signaling
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Reference #:
P70445
(UniProtKB)
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Alt. Names/Synonyms: 2810011I19Rik; 4E-BP; 4E-BP2; 4EBP2; AA792569; BC010348; eIF4E-binding protein 2; Eif4ebp2; eukaryotic translation initiation factor 4E binding protein 2; Eukaryotic translation initiation factor 4E-binding protein 2; MGC141219; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2
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Gene Symbols: Eif4ebp2
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Molecular weight:
12,898 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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