emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Skeletal muscle, heart, colon, testis, ovary and pancreas. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral
Chromosomal Location of Human Ortholog: X A7.3|X 37.92 cM
Cellular Component:  cytoplasm; endoplasmic reticulum; integral component of membrane; membrane; microtubule; nuclear envelope; nuclear inner membrane; nuclear lamina; nuclear membrane; nuclear outer membrane; nucleoplasm; nucleus; spindle
Molecular Function:  actin binding; beta-tubulin binding; protein binding
Biological Process:  cellular response to growth factor stimulus; negative regulation of canonical Wnt signaling pathway; negative regulation of fibroblast proliferation; positive regulation of protein export from nucleus; regulation of canonical Wnt signaling pathway; skeletal muscle cell differentiation
Reference #:  O08579 (UniProtKB)
Alt. Names/Synonyms: AW550900; Emd; Emerin; OTTMUSP00000019267; Sta
Gene Symbols: Emd
Molecular weight: 29,436 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

emerin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene