CDK6 a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK4 subfamily; CDK4 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5 A1|5 2.04 cM
Cellular Component:  cell projection; centrosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; ruffle
Molecular Function:  ATP binding; cyclin binding; cyclin-dependent protein kinase activity; FBXO family protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell dedifferentiation; cell differentiation; cell division; gliogenesis; hemopoiesis; hemopoietic progenitor cell differentiation; negative regulation of cell cycle; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of monocyte differentiation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; protein amino acid phosphorylation; regulation of cell proliferation; regulation of erythrocyte differentiation; regulation of gene expression; regulation of hematopoietic stem cell differentiation; T cell differentiation in thymus; type B pancreatic cell development
Reference #:  Q64261 (UniProtKB)
Alt. Names/Synonyms: 5830411I20; AI504062; Cdk6; Cell division protein kinase 6; CRK2; Cyclin-dependent kinase 6; Serine/threonine-protein kinase PLSTIRE
Gene Symbols: Cdk6
Molecular weight: 37,028 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene