CDK6 Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK4 subfamily; CDK4 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 5 A1|5 2.04 cM
Cellular Component:  cell projection; centrosome; cyclin D2-CDK6 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; mediator complex; nucleoplasm; nucleus; ruffle
Molecular Function:  ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; FBXO family protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity
Biological Process:  cell cycle; cell dedifferentiation; cell differentiation; cell division; cell quiescence; gliogenesis; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; hemopoiesis; negative regulation of cell cycle; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of monocyte differentiation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; protein phosphorylation; regulation of cell cycle; regulation of cell population proliferation; regulation of erythrocyte differentiation; regulation of gene expression; regulation of hematopoietic stem cell differentiation; response to 5-fluorouracil; T cell differentiation in thymus; type B pancreatic cell development
Reference #:  Q64261 (UniProtKB)
Alt. Names/Synonyms: 5830411I20; AI504062; Cdk6; Cdkn6; Cell division protein kinase 6; CR2 protein kinase; Crk; CRK2; Cyclin-dependent kinase 6; Serine/threonine-protein kinase PLSTIRE
Gene Symbols: Cdk6
Molecular weight: 37,028 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene