TfR Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. Belongs to the peptidase M28 family. M28B subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 16 B3|16 23.06 cM
Cellular Component:  basolateral plasma membrane; cell surface; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; early endosome; endosome; endosome membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; HFE-transferrin receptor complex; integral component of membrane; integral component of plasma membrane; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane
Molecular Function:  chaperone binding; double-stranded RNA binding; Hsp70 protein binding; identical protein binding; iron ion transmembrane transporter activity; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity
Biological Process:  cellular iron ion homeostasis; cellular response to drug; cellular response to extracellular stimulus; cellular response to iron ion; cellular response to leukemia inhibitory factor; endocytosis; iron ion transport; osteoclast differentiation; positive regulation of B cell proliferation; positive regulation of bone resorption; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; receptor-mediated endocytosis; transferrin transport
Reference #:  Q62351 (UniProtKB)
Alt. Names/Synonyms: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; mammary tumor virus receptor 1; Mtv; Mtvr; Mtvr-1; Mtvr1; p90; TfR; TfR1; Tfrc; transferrin receptor; Transferrin receptor protein 1; Trfr
Gene Symbols: Tfrc
Molecular weight: 85,731 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene