IRAP Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Belongs to the peptidase M1 family. Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.3; Membrane protein, integral; Protease
Chromosomal Location of rat Ortholog: 1q12
Cellular Component:  cell surface; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; insulin-responsive compartment; intracellular membrane-bounded organelle; intracellular organelle; membrane; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; vesicle
Molecular Function:  aminopeptidase activity; metalloaminopeptidase activity; metallopeptidase activity; peptide binding; zinc ion binding
Biological Process:  negative regulation of cold-induced thermogenesis; neuropeptide catabolic process; peptide catabolic process; positive regulation of blood pressure; protein catabolic process; proteolysis; regulation of blood pressure; regulation of long-term neuronal synaptic plasticity; response to hormone; signal transduction; SMAD protein signal transduction
Reference #:  P97629 (UniProtKB)
Alt. Names/Synonyms: aminopeptidase Vp165; Cystinyl aminopeptidase; GP160; Insulin-regulated membrane aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; Lnpep; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; Vesicle protein of 165 kDa; Vp165
Gene Symbols: Lnpep
Molecular weight: 117,201 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IRAP

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene