PRDX2 a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: EC 1.11.1.15; Oxidoreductase
Chromosomal Location of Human Ortholog: 19q11
Cellular Component:  cell; cytoplasm; cytosol
Molecular Function:  antioxidant activity; thioredoxin peroxidase activity
Biological Process:  activation of MAPK activity; cell redox homeostasis; cellular response to oxidative stress; homeostasis of number of cells; hydrogen peroxide catabolic process; hydrogen peroxide metabolic process; leukocyte activation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of reactive oxygen species metabolic process; negative regulation of T cell differentiation; oxidation-reduction process; positive regulation of blood coagulation; regulation of apoptotic process; regulation of hydrogen peroxide metabolic process; removal of superoxide radicals; respiratory burst involved in inflammatory response; response to lipopolysaccharide; response to oxidative stress; T cell proliferation; thymus development
Reference #:  P35704 (UniProtKB)
Alt. Names/Synonyms: NKEF-B; peroxiredoxin 2; Peroxiredoxin-2; Prdx2; Tdpx1; Thiol-specific antioxidant protein; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; TSA
Gene Symbols: Prdx2
Molecular weight: 21,784 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PRDX2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene