PRDX2 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase
Chromosomal Location of rat Ortholog: 19q11
Cellular Component:  cell; cytoplasm; cytosol
Molecular Function:  antioxidant activity; thioredoxin peroxidase activity
Biological Process:  activation of MAPK activity; cell redox homeostasis; cellular response to oxidative stress; homeostasis of number of cells; hydrogen peroxide catabolic process; hydrogen peroxide metabolic process; leukocyte activation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of reactive oxygen species metabolic process; negative regulation of T cell differentiation; oxidation-reduction process; positive regulation of blood coagulation; regulation of apoptotic process; regulation of hydrogen peroxide metabolic process; removal of superoxide radicals; respiratory burst involved in inflammatory response; response to lipopolysaccharide; response to oxidative stress; T cell proliferation; thymus development
Reference #:  P35704 (UniProtKB)
Alt. Names/Synonyms: NKEF-B; peroxiredoxin 2; Peroxiredoxin-2; Prdx2; Tdpx1; Thiol-specific antioxidant protein; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; TSA
Gene Symbols: Prdx2
Molecular weight: 21,784 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene