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PRDX2
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.11.1.15; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 8 C3|8 41.4 cM |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
antioxidant activity; oxidoreductase activity; peroxidase activity; peroxiredoxin activity; protein binding; selenium binding; thioredoxin peroxidase activity; thioredoxin-dependent peroxiredoxin activity
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Biological Process:
cell redox homeostasis; cellular response to oxidative stress; cellular response to stress; defense response to tumor cell; extrinsic apoptotic signaling pathway; hydrogen peroxide catabolic process; hydrogen peroxide metabolic process; leukocyte activation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell differentiation; positive regulation of blood coagulation; positive regulation of MAPK cascade; regulation of apoptotic process; regulation of hydrogen peroxide metabolic process; removal of superoxide radicals; respiratory burst involved in inflammatory response; response to lipopolysaccharide; response to oxidative stress; T cell homeostasis; T cell proliferation; thymus development
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Reference #:
Q61171
(UniProtKB)
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Alt. Names/Synonyms: AL022839; Band-8; Calpromotin; NKEF-B; NkefB; OTTMUSP00000018421; OTTMUSP00000018422; OTTMUSP00000018423; peroxiredoxin 2; Peroxiredoxin-2; Prdx2; protector protein; PRP; Prx II-1; PrxII; Tdpx; Tdpx1; TDX1; thiol specific antioxidant protein; Thiol-specific antioxidant protein; thioredoxin dependent peroxide reductase 1; Thioredoxin peroxidase 1; thioredoxin reductase; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; Torin; Tpx; TPx-B; Trx dependent peroxide reductase 1; TSA
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Gene Symbols: Prdx2
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Molecular weight:
21,779 Da
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Basal Isoelectric point:
5.2
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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