KCNT1 Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 3p13
Cellular Component:  integral component of membrane; plasma membrane
Molecular Function:  intracellular sodium activated potassium channel activity; outward rectifier potassium channel activity; potassium channel activity
Biological Process:  potassium ion transmembrane transport; potassium ion transport; regulation of membrane potential
Reference #:  Q9Z258 (UniProtKB)
Alt. Names/Synonyms: Kcnt1; Potassium channel subfamily T member 1; rSlo2; Sequence like a calcium-activated potassium channel subunit; Slack
Gene Symbols: Kcnt1
Molecular weight: 139,615 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene