NCK1 adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9|9 E3.3
Cellular Component:  cell-cell junction; cytoplasm; endoplasmic reticulum; nucleus; protein phosphatase type 1 complex; ribosome; vesicle membrane
Molecular Function:  ephrin receptor binding; eukaryotic initiation factor eIF2 binding; protein binding; protein domain specific binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity; signaling receptor binding
Biological Process:  actin filament organization; cell migration; ephrin receptor signaling pathway; lamellipodium assembly; negative regulation of cell death; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; peptidyl-serine dephosphorylation; positive regulation of actin filament polymerization; positive regulation of cap-dependent translational initiation; positive regulation of cap-independent translational initiation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of neuron projection development; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation in response to endoplasmic reticulum stress; regulation of cell migration; regulation of translation; response to other organism; substrate-dependent cell migration, cell extension; T cell activation
Reference #:  Q99M51 (UniProtKB)
Alt. Names/Synonyms: 6330586M15Rik; Cytoplasmic protein NCK1; D230010O13Rik; Nck; Nck1; non-catalytic region of tyrosine kinase adaptor protein 1; OTTMUSP00000023124; SH2/SH3 adaptor protein
Gene Symbols: Nck1
Molecular weight: 42,891 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene