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NCK1
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 9|9 E3.3 |
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Cellular Component:
cell-cell junction; cytoplasm; cytosol; endoplasmic reticulum; nucleus; plasma membrane; protein phosphatase type 1 complex; ribosome; vesicle membrane
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Molecular Function:
ephrin receptor binding; eukaryotic initiation factor eIF2 binding; molecular condensate scaffold activity; protein binding; protein domain specific binding; protein kinase inhibitor activity; protein-macromolecule adaptor activity; receptor tyrosine kinase binding; signaling adaptor activity; signaling receptor binding
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Biological Process:
actin filament organization; antiviral innate immune response; cell migration; ephrin receptor signaling pathway; lamellipodium assembly; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; peptidyl-serine dephosphorylation; positive regulation of actin filament polymerization; positive regulation of cap-dependent translational initiation; positive regulation of cap-independent translational initiation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of neuron projection development; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation in response to endoplasmic reticulum stress; regulation of cell migration; regulation of translation; response to other organism; signal transduction; substrate-dependent cell migration, cell extension; T cell activation
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Reference #:
Q99M51
(UniProtKB)
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Alt. Names/Synonyms: 6330586M15Rik; Cytoplasmic protein NCK1; D230010O13Rik; Nck; NCK adaptor protein 1; Nck-1; Nck1; non-catalytic region of tyrosine kinase adaptor protein 1; OTTMUSP00000023124; SH2/SH3 adaptor protein
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Gene Symbols: Nck1
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Molecular weight:
42,891 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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ErbB/HER Signaling
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Insulin Receptor Signaling
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T Cell Receptor Signaling
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Translation: eIF2
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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