MAX Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Belongs to the MAX family. High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12 C3|12 33.78 cM
Cellular Component:  cell projection; cytoplasm; dendrite; MLL1 complex; nuclear chromatin; nucleus; PML body; protein-DNA complex; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P28574 (UniProtKB)
Alt. Names/Synonyms: AA960152; AI875693; bHLHd; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Max; Max protein; Myc-associated factor X; Myc-binding novel HLH/LZ protein; Myn; Protein max; Protein myn
Gene Symbols: Max
Molecular weight: 18,245 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MAX

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene