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MAX
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Belongs to the MAX family. High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 12 C3|12 33.78 cM |
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Cellular Component:
cell projection; cytoplasm; dendrite; MLL1 complex; nuclear chromatin; nucleus; PML body; protein-DNA complex; RNA polymerase II transcription factor complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
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Biological Process:
negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
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Reference #:
P28574
(UniProtKB)
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Alt. Names/Synonyms: AA960152; AI875693; bHLHd; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Max; Max protein; Myc-associated factor X; Myc-binding novel HLH/LZ protein; Myn; Protein max; Protein myn
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Gene Symbols: Max
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Molecular weight:
18,245 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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CST Pathways:
Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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