CHAT Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Belongs to the carnitine/choline acetyltransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 14 B|14 19.4 cM
Cellular Component:  axon; cytoplasm; neuron projection; neuronal cell body
Molecular Function:  choline binding; choline O-acetyltransferase activity; transferase activity; transferase activity, transferring acyl groups
Biological Process:  acetylcholine biosynthetic process; adult walking behavior; chemical synaptic transmission; dendrite development; establishment of synaptic specificity at neuromuscular junction; memory; muscle organ development; neuromuscular synaptic transmission; neuron differentiation; neurotransmitter biosynthetic process; rhythmic behavior; rhythmic excitation
Reference #:  Q03059 (UniProtKB)
Alt. Names/Synonyms: B230380D24Rik; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O-acetyltransferase; CLAT
Gene Symbols: Chat
Molecular weight: 71,853 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CHAT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene