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CHAT
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Belongs to the carnitine/choline acetyltransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid |
| Chromosomal Location of human Ortholog: 10q11.23 |
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Cellular Component:
cytoplasm; cytosol; neuron projection; nucleus; synapse
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Molecular Function:
choline O-acetyltransferase activity
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Biological Process:
acetylcholine biosynthetic process; neuromuscular synaptic transmission; neurotransmitter transport; phosphatidylcholine biosynthetic process
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Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea
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Reference #:
P28329
(UniProtKB)
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Alt. Names/Synonyms: acetyl CoA:choline O-acetyltransferase; CHAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O-acetyltransferase; CLAT; CMS1A; CMS1A2; CMS6
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Gene Symbols: CHAT
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Molecular weight:
82,536 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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