CHAT Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Belongs to the carnitine/choline acetyltransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 10q11.23
Cellular Component:  cytosol; nucleus; presynapse
Molecular Function:  choline O-acetyltransferase activity
Biological Process:  neurotransmitter secretion; phosphatidylcholine biosynthetic process
Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea
Reference #:  P28329 (UniProtKB)
Alt. Names/Synonyms: acetyl CoA:choline O-acetyltransferase; CHAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O-acetyltransferase; CLAT; CMS1A; CMS1A2
Gene Symbols: CHAT
Molecular weight: 82,536 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein