WWOX Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor
Chromosomal Location of human Ortholog: 16q23.1-q23.2
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; microvillus; mitochondrion; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex
Molecular Function:  enzyme binding; oxidoreductase activity; protein binding; transcription coactivator activity
Biological Process:  cellular response to transforming growth factor beta stimulus; extrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of Wnt signaling pathway; osteoblast differentiation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of transcription by RNA polymerase II; skeletal system morphogenesis; Wnt signaling pathway
Disease: Epileptic Encephalopathy, Early Infantile, 28; Esophageal Cancer; Spinocerebellar Ataxia, Autosomal Recessive 12
Reference #:  Q9NZC7 (UniProtKB)
Alt. Names/Synonyms: D16S432E; EIEE28; FOR; FRA16D; Fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SCAR12; SDR41C1; Short chain dehydrogenase/reductase family 41C member 1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX
Gene Symbols: WWOX
Molecular weight: 46,677 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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