MYO6 iso7
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. May play a role in the extension and network organization of neurites. Required for structural integrity of inner ear hair cells. Modulates RNA polymerase II-dependent transcription. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Molecular Function: actin binding; actin filament binding; ATP binding; calmodulin binding; cytoskeletal motor activity; identical protein binding; microfilament motor activity; nucleotide binding; protein binding
Biological Process: actin filament organization; cellular response to electrical stimulus; chemical synaptic transmission; dendrite development; DNA damage response, signal transduction by p53 class mediator; endocytosis; glutamate secretion; inner ear auditory receptor cell differentiation; inner ear development; inner ear morphogenesis; locomotory behavior; postsynaptic neurotransmitter receptor internalization; presynaptic modulation of chemical synaptic transmission; protein targeting; protein transport; regulation of secretion; regulation of synaptic plasticity; response to xenobiotic stimulus; sensory perception of sound; synapse assembly; vesicle transport along actin filament