PLB Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Belongs to the phospholamban family. Heart muscle (at protein level). Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Membrane protein, integral
Cellular Component:  calcium ion-transporting ATPase complex; endoplasmic reticulum membrane; mitochondrial membrane; sarcoplasmic reticulum membrane
Molecular Function:  ATPase inhibitor activity; protein homodimerization activity
Biological Process:  acrosome assembly; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; cardiac muscle tissue development; intracellular calcium ion homeostasis; muscle cell cellular homeostasis; negative regulation of ATP-dependent activity; negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of calcium ion binding; negative regulation of calcium ion import into sarcoplasmic reticulum; negative regulation of calcium ion transmembrane transporter activity; Notch signaling pathway; regulation of calcium ion import; regulation of calcium ion transport; regulation of cardiac muscle cell contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of relaxation of muscle; regulation of ryanodine-sensitive calcium-release channel activity; regulation of the force of heart contraction by cardiac conduction
Reference #:  P61012 (UniProtKB)
Alt. Names/Synonyms: Cardiac phospholamban; phospholamban; PLB; PLN; PPLA; PPLAx
Gene Symbols: PLN
Molecular weight: 6,080 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
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PLB

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene