G3BP-1 ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC; EC; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 11|11 B1.3
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nucleus; ribonucleoprotein complex
Molecular Function:  ATP binding; DNA binding; endonuclease activity; helicase activity; hydrolase activity; mRNA binding; nuclease activity; nucleic acid binding; nucleotide binding; protein binding; RNA binding
Biological Process:  defense response to virus; negative regulation of canonical Wnt signaling pathway; positive regulation of stress granule assembly; stress granule assembly; type I interferon production
Reference #:  P97855 (UniProtKB)
Alt. Names/Synonyms: AI849976; ATP-dependent DNA helicase VIII; B430204O07; C87777; G3bp; G3BP-1; G3bp1; GAP SH3 binding protein; GAP SH3 domain-binding protein 1; GTPase activating protein (SH3 domain) binding protein 1; HDH-VIII; KIAA4115; mKIAA4115; OTTMUSP00000005871; Ras GTPase-activating protein-binding protein 1; Ras-GTPase-activating protein SH3-domain binding protein 1
Gene Symbols: G3bp1
Molecular weight: 51,829 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein