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G3BP-1
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding |
| Chromosomal Location of human Ortholog: 5q33.1 |
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Cellular Component:
cytoplasm; cytoplasmic stress granule; cytosol; nucleus; perikaryon
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Molecular Function:
ATP binding; ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; DNA binding; endonuclease activity; protein binding
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Biological Process:
defense response to virus; DNA duplex unwinding; negative regulation of canonical Wnt signaling pathway; nucleic acid phosphodiester bond hydrolysis; positive regulation of stress granule assembly; Ras protein signal transduction; stress granule assembly; type I interferon production; viral process
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Reference #:
Q13283
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent DNA helicase VIII; DNA helicase VIII; G3BP; G3BP stress granule assembly factor 1; G3BP-1; G3BP1; GAP binding protein; GAP SH3 domain-binding protein 1; GTPase activating protein (SH3 domain) binding protein 1; hDH VIII; HDH-VIII; MGC111040; Ras GTPase-activating protein-binding protein 1; Ras-GTPase-activating protein SH3-domain-binding protein; RasGAP-associated endoribonuclease G3BP
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Gene Symbols: G3BP1
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Molecular weight:
52,164 Da
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Basal Isoelectric point:
5.36
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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