TACE Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: actin cytoskeleton; apical part of cell; apical plasma membrane; cell surface; cell-cell junction; cytoplasm; cytoplasmic vesicle; cytosol; focal adhesion; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; ruffle membrane

Molecular Function: endopeptidase activity; integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; SH3 domain binding

Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility; cellular response to high density lipoprotein particle stimulus; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; germinal center formation; integrin-mediated signaling pathway; membrane protein ectodomain proteolysis; negative regulation of apoptotic process; negative regulation of cold-induced thermogenesis; negative regulation of neuron projection development; negative regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of apoptotic process; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of chemokine production; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of neuron projection development; positive regulation of protein phosphorylation; positive regulation of T cell chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of vascular endothelial cell proliferation; production of molecular mediator involved in inflammatory response; proteolysis; receptor transactivation; regulation of axon regeneration; regulation of mast cell apoptotic process; regulation of neuron migration; response to antineoplastic agent; response to drug; response to hypobaric hypoxia; response to hypoxia; response to lipopolysaccharide; spermatogenesis; spleen development; T cell differentiation in thymus; tumor necrosis factor-mediated signaling pathway; wound healing, spreading of epidermal cells

Reference #: Q9Z1K9 (UniProtKB)

Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADA17; ADAM 17; ADAM metallopeptidase domain 17; Adam17; Disintegrin and metalloproteinase domain-containing protein 17; Tace; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme

Gene Symbols: Adam17

Molecular weight: 93,017 Da

Basal Isoelectric point: 5.54 Predict pI for various phosphorylation states

CST Pathways: Alzheimer's Disease | ErbB/HER Signaling | Notch Signaling

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TACE

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