TNNT2 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin T family. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of human Ortholog: 1q32.1
Cellular Component:  cardiac myofibril; cardiac Troponin complex; cytosol; sarcomere; striated muscle thin filament; troponin complex
Molecular Function:  actin binding; protein binding; tropomyosin binding; troponin C binding; troponin I binding
Biological Process:  cardiac muscle contraction; muscle filament sliding; negative regulation of ATP-dependent activity; positive regulation of ATP-dependent activity; regulation of heart contraction; regulation of muscle contraction; response to calcium ion; sarcomere organization; ventricular cardiac muscle tissue morphogenesis
Disease: Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2; Cardiomyopathy, Familial Restrictive, 3
Reference #:  P45379 (UniProtKB)
Alt. Names/Synonyms: Cardiac muscle troponin T; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMD1D; CMH2; CMPD2; cTnT; LVNC6; MGC3889; RCM3; TNNT2; TnTc; troponin T type 2 (cardiac); troponin T type 2, cardiac; Troponin T, cardiac muscle; troponin T2, cardiac; troponin T2, cardiac type; truncated cardiac troponin T
Gene Symbols: TNNT2
Molecular weight: 35,924 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein