STAT5B Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Belongs to the transcription factor STAT family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10q31
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; glucocorticoid receptor binding; protein binding; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  acute-phase response; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; cellular response to hormone stimulus; cytokine-mediated signaling pathway; defense response; development of secondary female sexual characteristics; development of secondary male sexual characteristics; female pregnancy; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; lactation; lipid storage; liver development; luteinization; mast cell migration; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of erythrocyte differentiation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of lymphocyte differentiation; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; progesterone metabolic process; regulation of cell adhesion; regulation of cell proliferation; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to estradiol; response to ethanol; response to hypoxia; response to interleukin-15; response to interleukin-2; response to interleukin-4; response to lipopolysaccharide; response to peptide hormone; sex differentiation; T cell differentiation in thymus; T cell homeostasis; taurine metabolic process; transcription by RNA polymerase II
Reference #:  P52632 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 5a; Signal transducer and activator of transcription 5B; STA5B; Stat5b
Gene Symbols: Stat5b
Molecular weight: 90,223 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STAT5B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene