RGS9 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction. Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of mouse Ortholog: 11 E1|11 71.86 cM
Cellular Component:  cytoplasm; glutamatergic synapse; membrane; neuron projection; plasma membrane; postsynaptic density membrane; presynaptic membrane
Molecular Function:  GTPase activator activity; protein binding
Biological Process:  dark adaptation; dopamine receptor signaling pathway; G protein-coupled receptor signaling pathway; intracellular signal transduction; light adaption; negative regulation of signal transduction; positive regulation of GTPase activity; positive regulation of NMDA glutamate receptor activity; regulation of calcium ion export across plasma membrane; regulation of G protein-coupled receptor signaling pathway; response to stimulus; visual perception
Reference #:  O54828 (UniProtKB)
Alt. Names/Synonyms: MGC150267; MGC150268; OTTMUSP00000003041; Regulator of G-protein signaling 9; RGS9; RGS9-1; Rgs9-2; ROS GAP
Gene Symbols: Rgs9
Molecular weight: 76,978 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein