Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Belongs to the intermediate filament family. Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 A1|2 10.04 cM
Cellular Component:  axon; cell body; cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; intermediate filament; neuron projection; nucleus; perinuclear region of cytoplasm; peroxisome; phagocytic vesicle; plasma membrane; polysome; ribonucleoprotein complex; type III intermediate filament
Molecular Function:  double-stranded RNA binding; identical protein binding; keratin filament binding; kinase binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase 2A binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of eye lens; structural molecule activity
Biological Process:  astrocyte development; Bergmann glial cell differentiation; cellular response to interferon-gamma; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; intermediate filament organization; intermediate filament-based process; lens fiber cell development; negative regulation of neuron projection development; positive regulation of collagen biosynthetic process; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of translation; regulation of axonogenesis; regulation of mRNA stability; regulation of Schwann cell migration; SMAD protein signal transduction
Reference #:  P20152 (UniProtKB)
Alt. Names/Synonyms: MGC102095; OTTMUSP00000012058; Vim; VIME; Vimentin
Gene Symbols: Vim
Molecular weight: 53,688 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene